Add the pork and beans, red beans, pinto beans, and kidney beans to the bowl of your slow cooker.
Add the bacon, ketchup, brown sugar, molasses, Worcestershire sauce, and mustard to the beans. Stir well to mix.
In a small bowl, mix the paprika, salt, sugar, cumin, garlic powder, mustard powder, black pepper, and cayenne pepper together. Add the spice mixture to the bean mixture and stir to combine.
Cook on LOW for 6 hours or HIGH for four hours, stirring occasionally.